Busoga sub-region is a region in Eastern Uganda, it occupies an area of over 10,000 square kilometers and according to the 2014 national census about 40 percent of the people in the eastern region live in this sub region.

The sub-region is home mainly to the Basoga ethnic group. The people of Busoga are called Basoga (singular: Musoga). The Basoga speak Lusoga, a Bantu language. Lusoga is similar to Luganda, spoken by the people of the neighboring Buganda Region, which is also referred to as Central Uganda.

Busoga consists of the following districts.